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Disease Screening

What is a disease screening Score ?

The intention of a disease screening test or disease trend, is to identify the possibility of disease or disorder without symptoms. The screening score of a disease/disorder is related to the statistical analysis of the specificity and sensitivity of the markers related to the disease or disorder.

The screening score should be used to indicate the need for further evaluation – not as a basis for diagnosis.

How the screening score is used?


The negative results (sub-clinical means not detected by the conventional tests) of a screening score will allow the use of preventive medicine at a time when lifestyle intervention may be useful therapy.

Health Care Software Solution New approach of the Diseases Screening:


The Essential Hypertension Causes: New concept and validation

Arterial stiffness is increasingly recognized as an important prognostic index and potential therapeutic target in patients with hypertension. Aortic stiffness and arterial pulse wave reflections are key determinants of elevated central systolic pressure and are associated with adverse cardiovascular outcomes. Indeed, the 2003 European Society of Hypertension guidelines on the management of hypertension acknowledge the potential role of arterial stiffness measurement in clinical management . 1. European Society of Hypertension-European Society of Cardiology Guidelines Committee. 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens. 2003; 21: 1011–1053.

2. Agabiti-Rosei E, Mancia G, O'Rourke MF, Roman MJ, Safar ME, Smulyan H, Wang JG, Wilkinson IB, Williams B, Vlachopoulos C. Central blood pressure measurements and antihypertensive therapy: a consensus document. Hypertension. 2007; 50: 154–160.

3 Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006; 27: 2588–2605.

The Cardiac output measurement requirement in the hypertension treatment

Diseases of the cardiovascular system are often associated with changes in hemodynamic indicators and in particular the cardiac output (Q) with the pandemic diseases of hypertension and heart failure. Cardiovascular disease can be associated with increased Q as occurs during infection and sepsis, or decreased Q, as in cardiomyopathy and heart failure. The ability to accurately measure Q is important in clinical medicine as it provides for improved diagnosis of abnormalities, and can be used to guide appropriate therapeutic management.

Q measurement, if it were accurate and non-invasive, would be adopted as part of every clinical examination from general observations to the intensive care ward, and would be as common as simple blood pressure measurements are now. Such practice, if it were adopted, may revolutionize the treatment of many cardiovascular diseases including hypertension and heart failure.

Insulin resistance is linked to a range of cardiovascular risk factors

These risk factors are known as the Metabolic Syndrome or Insulin Resistance Syndrome. Components of the Metabolic Syndrome include well known cardiovascular risk factors such as hyperglycemia, dyslipidemia and hypertension. Additional cardiovascular risk factors, that is, damage to blood vessels (endothelial dysfunction), clotting abnormalities (hypofibrinolysis) and inflammation, have also been recognized as key components of the Metabolic Syndrome.

Together, the cluster of cardiovascular risk factors that make up the Metabolic Syndrome significantly increases the risk of atherosclerosis.